I've been using these for almost 4 years now, and I could tell a difference within a month of starting them. I believe in them so much, I talked my husband into taking them. He apparently had a gut issue they started repairing, which led us to discover he has a sensitivity/allergy to dairy. He went about 3 weeks recently taking just every other day to help us conserve while waiting for PB to restock and he said he could tell a difference in how he felt. That's a HUGE admission for him. They work although since everyone is different, your mileage may vary.